Spravato® (Esketamine) Treatment
A New Approach for Treatment-Resistant Depression
For individuals living with depression that has not improved despite trying multiple antidepressant medications, Spravato® (esketamine) may provide another treatment option.
Spravato is an FDA-approved nasal spray treatment used for adults with treatment-resistant depression and certain cases of major depressive disorder. It works differently from traditional antidepressants by targeting the brain's glutamate system, which plays an important role in neural communication and mood regulation.
What Is Spravato?
Spravato contains esketamine, a medication derived from ketamine and administered as a nasal spray under medical supervision.
Unlike many traditional antidepressants that may take weeks to show benefits, Spravato may provide symptom improvement more rapidly for some patients.
Who May Be Eligible?
Spravato may be considered for adults who:
Have treatment-resistant depression
Have not responded to multiple antidepressants
Continue experiencing significant depressive symptoms
Meet clinical eligibility requirements
How Spravato Works
Researchers believe Spravato affects NMDA receptors and supports neural connectivity involved in mood regulation. This mechanism differs from traditional antidepressants, making it a unique treatment option.
What to Expect During Treatment
Treatment takes place in a certified medical setting.
The process generally includes:
Clinical evaluation
Eligibility review
Administration of nasal spray
Observation period
Follow-up treatment planning
Patients are monitored following each session as part of established safety protocols.
Benefits of Spravato
FDA-approved treatment
Different mechanism of action
Option for treatment-resistant depression
Administered under professional supervision
May provide relief for individuals who have not responded to conventional treatments
Frequently Asked Questions
How is Spravato different from traditional antidepressants?
It works through different brain pathways than many standard antidepressants.
Is Spravato covered by insurance?
Many insurance providers offer coverage depending on eligibility requirements.
How long does treatment take?
The treatment schedule varies based on individual clinical needs and provider recommendations.
